Takayasu’s arteritis is among the most common diseases from the group of vasculitis, also known as Aortic arch syndrome or non-pulse disease as inflammatory process frequently comprise subclavian artery. Takayasu’s arteritis is a chronic granulomatous vasculitis involving the arteries of large and medium caliber, mainly the aorta and its main branches capital, including blood supply to the brain. Inflammatory process covers middle and the innermost layer (intima and media) of the vessels. Effect on vascular walls cause aneurysmal widening and narrowing of the arteries, predisposes to thrombosis by completely blocking the patency of the arteries. In severe injuries disrupting blood supply to tissues and organs, although usually the formed collateral circulation. Particularly dangerous are the living conditions in which they are affected blood vessels to vital organs such as the brain, lungs, kidney and the like.
Although it occurs in men, the disease mainly affects women at a young age. Not yet specified the reasons for the development of the syndrome of the aortic arch, but is suspected genetic predisposition to the disease.
Early in the disease, patients most often complain of fatigue, tiredness, loss of appetite and weight. Other unspecific symptoms are dizziness, muscle pain, night sweats, arthritis. With the progression of the inflammatory processes appear and characteristic symptoms such as pain over the affected arteries. If the disease is not diagnosed and begin treatment promptly begin ischemic changes. It affects the blood supply to the heart, which clinically manifested by seizures resembling angina. The involvement of the aorta in the part in which proceeds from the heart with coverage of aortic valve insufficiency leads to the last and shaping of heart failure over the years. In impairment of cerebral blood flow, patients complain of dizziness, prolonged and severe headaches and mood changes with emotional instability, tendency to depression, etc.
Sadoveta bottlenecks in the limbs can provoke weakness, fatigue their muksuli pain during exercise. Especially often affected artery, reflux upper limbs, which affects the pulse – a key trait for the disease – missing or faint pulse on one of the upper extremities – usually asitmetrichno with measurable difference in blood pressure on both arms. The reasons for this disease is often called bezpulsova disease. Missing or too weak pulse, though in rare cases can be established and the lower extremities. Typically the disease is the presence of arterial noises that are perceived best over the carotid and subclavian artery. A subset of patients may be established hypertension due to renal artery coverage of the inflammatory process. Engaging vessels sprinkling tract presents with abdominal pain.